SB-271046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6 receptors as a target, with an initial lead compound being developed into SB-271046 through a structure-activity relationship (SAR) study. SB-271046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood–brain barrier, so further SAR work was then conducted, which led to improved 5-HT6 antagonists such as SB-357,134 and SB-399,885.
"}{"type":"standard","title":"Symbiotes gibberosus","displaytitle":"Symbiotes gibberosus","namespace":{"id":0,"text":""},"wikibase_item":"Q3158767","titles":{"canonical":"Symbiotes_gibberosus","normalized":"Symbiotes gibberosus","display":"Symbiotes gibberosus"},"pageid":57000758,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/4/40/Symbiotes_gibberosus_Jacobson.png","width":310,"height":390},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/4/40/Symbiotes_gibberosus_Jacobson.png","width":310,"height":390},"lang":"en","dir":"ltr","revision":"1214409964","tid":"c84adc07-e561-11ee-a5fe-5b1b838a3b4a","timestamp":"2024-03-18T19:57:43Z","description":"Species of beetle","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Symbiotes_gibberosus","revisions":"https://en.wikipedia.org/wiki/Symbiotes_gibberosus?action=history","edit":"https://en.wikipedia.org/wiki/Symbiotes_gibberosus?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Symbiotes_gibberosus"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Symbiotes_gibberosus","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Symbiotes_gibberosus","edit":"https://en.m.wikipedia.org/wiki/Symbiotes_gibberosus?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Symbiotes_gibberosus"}},"extract":"Symbiotes gibberosus is a species of beetle in the family Anamorphidae. It is found in Africa, Europe and Northern Asia, and North America.","extract_html":"
Symbiotes gibberosus is a species of beetle in the family Anamorphidae. It is found in Africa, Europe and Northern Asia, and North America.
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{"slip": { "id": 155, "advice": "What could you increase? What could you reduce?"}}
{"slip": { "id": 154, "advice": "State the problem in words as clearly as possible."}}
{"fact":"The technical term for a cat\u2019s hairball is a \u201cbezoar.\u201d","length":54}
{"type":"standard","title":"Mikko Lehtonen (ice hockey, born 1978)","displaytitle":"Mikko Lehtonen (ice hockey, born 1978)","namespace":{"id":0,"text":""},"wikibase_item":"Q59787","titles":{"canonical":"Mikko_Lehtonen_(ice_hockey,_born_1978)","normalized":"Mikko Lehtonen (ice hockey, born 1978)","display":"Mikko Lehtonen (ice hockey, born 1978)"},"pageid":7415991,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/3/33/MikkoLehtonenTimr%C3%A5.jpg","width":301,"height":609},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/3/33/MikkoLehtonenTimr%C3%A5.jpg","width":301,"height":609},"lang":"en","dir":"ltr","revision":"1290087075","tid":"9665b2b7-2f63-11f0-bc5b-a97fd6c1f143","timestamp":"2025-05-12T19:02:02Z","description":"Finnish ice hockey player","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Mikko_Lehtonen_(ice_hockey%2C_born_1978)","revisions":"https://en.wikipedia.org/wiki/Mikko_Lehtonen_(ice_hockey%2C_born_1978)?action=history","edit":"https://en.wikipedia.org/wiki/Mikko_Lehtonen_(ice_hockey%2C_born_1978)?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Mikko_Lehtonen_(ice_hockey%2C_born_1978)"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Mikko_Lehtonen_(ice_hockey%2C_born_1978)","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Mikko_Lehtonen_(ice_hockey%2C_born_1978)","edit":"https://en.m.wikipedia.org/wiki/Mikko_Lehtonen_(ice_hockey%2C_born_1978)?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Mikko_Lehtonen_(ice_hockey%2C_born_1978)"}},"extract":"Mikko Tapani Lehtonen is a Finnish former ice hockey defenceman. He played 15 games in the National Hockey League with the Nashville Predators during the 2006–07 season. The rest